• MADE IN USA

  • GMP CERTIFIED

  • THIRD PARTY TESTED

  • ZERO FILLERS

  • 30 DAY MONEY BACK GUARANTEE

  • MADE IN USA

  • GMP CERTIFIED

  • THIRD PARTY TESTED

  • ZERO FILLERS

  • 30 DAY MONEY BACK GUARANTEE

  • MADE IN USA

  • GMP CERTIFIED

  • THIRD PARTY TESTED

  • ZERO FILLERS

  • 30 DAY MONEY BACK GUARANTEE

  • MADE IN USA

  • GMP CERTIFIED

  • THIRD PARTY TESTED

  • ZERO FILLERS

  • 30 DAY MONEY BACK GUARANTEE

  • MADE IN USA

  • GMP CERTIFIED

  • THIRD PARTY TESTED

  • ZERO FILLERS

  • 30 DAY MONEY BACK GUARANTEE

Coffee's Real Secret

Boost NAD+ for Strength, Endurance, and Focus
1 3

Trigonelline

Backed by 2024 Nature Metabolism study
$52.90 $52.90

Trigonelline boosts NAD+ levels directly in muscle tissue—fueling ATP synthesis for peak cellular energy and healthy aging. By enhancing mitochondrial efficiency and red blood cell performance, it improves oxygen delivery to muscles, sustaining endurance, reducing fatigue, and powering strength for optimal performance.

Trigonelline enhances glucose uptake and insulin sensitivity to stabilize blood sugar, while supporting healthy fat metabolism and efficient glycogen storage—delivering sustained energy, improved endurance, and overall metabolic resilience.

Trigonelline boosts NAD+ to fuel neuronal energy and mitochondrial function, sharpening memory, focus, and learning. By enhancing neuroprotection, reducing neuroinflammation, and improving cerebral blood flow, it supports mental clarity, mood balance, and long-term brain health.
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NATURALLY FOUND IN COFFEE

Unlock Energy, endurance, and focus

Naturally found in coffee, Trigonelline is a potent NAD+ precursor that powers cellular energy, resilience, and performance. By elevating NAD+ directly in muscle and brain tissue, it fuels ATP synthesis for strength, endurance, and healthy aging.

Trigonelline enhances mitochondrial efficiency, oxygen delivery, and glucose metabolism—stabilizing blood sugar, optimizing fat utilization, and sustaining energy. It also sharpens memory, focus, and learning by supporting neuronal energy, neuroprotection, and cerebral blood flow.

Backed by emerging research and trusted by athletes and longevity enthusiasts, our 300mg Trigonelline capsules deliver clean, jitter-free performance and cognitive clarity.

Trigonelline Research

science-backed results

The lastest research behind trigonelline

Read more
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The Complete Benefits of Trigonelline: Cognitive Clarity, Strength, and Cellular Resilience

May 2025

Recent research reveals Trigonelline's role as a direct NAD⁺ precursor that supports everything from mental clarity to mitochondrial biogenesis, muscle strength to metabolic health. Unlike older precursors like NR or NMN, Trigonelline bypasses the liver, crosses the blood-brain barrier, and reaches muscle tissue directly.
Read More
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Trigonelline and the Brain: NAD+, Neuroprotection, and Cognitive Precision

May 2025

Trigonelline restores NAD⁺ directly in brain tissue. In the Nature Metabolism 2024 study, trigonelline was detected in cerebrospinal fluid, confirming central nervous system uptake - a level of access most NAD⁺ precursors never achieve. 
Read More
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Trigonelline for Peak Performance: The Molecule for Powering Strength, Endurance, and Recovery

April 2025

Recent Trigonelline research published on this naturally occurring alkaloid highlights its potential in enhancing muscle function and combating age-related decline.
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Trigonelline and Muscle Health: Insights from Nestlé's Research

February 2025

A 2024 study published in Nature Metabolism, conducted by researchers from EPFL in collaboration with the Nestlé Institute of Health Sciences identifies Trigonelline as a novel precursor to NAD+, a critical molecule for cellular energy production. 
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Customer Reviews

Based on 17 reviews
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6%
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E
Eugene
Very effective

Very effective, notice pretty rapidly, will be reordering.

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Gregory Deyermenjian
Trigonelline, up to now (just beginning)

I like all I have read and watched concerning Trigonelline, as well as all of its friendly and professional staff with whom I have dealt. I am at the beginning stages of using the product, and I have high expectations concerning its efficacy.

D
Dominic Vincent
Good coffee alternative

I love coffee but it doesn’t love me. These supplements provide me the boost I need without the downsides.

S
Stephen Andrade

Product definitely helps me focus

R
Rod Stair

Just received order yesterdayu

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