This powerful alkaloid has captured attention for its unique ability to directly increase NAD+ in muscle tissue—unlike other precursors that get lost in translation. From fueling endurance to sharpening focus, Trigonelline unlocks an entirely new tier of human potential.

Trigonelline is a naturally occurring alkaloid found in coffee, legumes, and plants — but in trace amounts.

It belongs to a class of compounds known as NAD+ precursors, meaning it can elevate NAD+ levels in your cells — the master molecule responsible for cellular energy, repair, and longevity.

Unlike NMN or NR, which primarily circulate and benefit systemic NAD+ pools, Trigonelline preferentially boosts NAD+ where it matters most for performance: in muscle tissue.

This makes it an exceptional choice for athletes, biohackers, and anyone looking to push their limits.

Not all Trigonelline is created equal. In fact, one form isn’t even meant for human consumption.

When choosing a Trigonelline supplement, the form matters. Here’s why:

Methylated Niacin (N-methyl-nicotinic acid): Unstable and Unsuitable

While technically a form of Trigonelline, methylated niacin suffers from a critical flaw:

it’s chemically unstable in normal storage conditions and prone to rapid degradation.

Peer-reviewed research has confirmed this instability:

"Trigonelline (N-methylnicotinic acid) is unstable under neutral and alkaline conditions... degradation proceeds rapidly at higher temperatures and during storage."
— Gokmen V. et al., European Food Research and Technology, 2005

"N-methylated forms of niacin are readily decomposed during storage and processing... unsuitable for stable supplementation products."

— Klein et al., Journal of Agricultural and Food Chemistry, 2003