• MADE IN USA

  • GMP CERTIFIED

  • THIRD PARTY TESTED

  • ZERO FILLERS

  • 30 DAY MONEY BACK GUARANTEE

  • MADE IN USA

  • GMP CERTIFIED

  • THIRD PARTY TESTED

  • ZERO FILLERS

  • 30 DAY MONEY BACK GUARANTEE

  • MADE IN USA

  • GMP CERTIFIED

  • THIRD PARTY TESTED

  • ZERO FILLERS

  • 30 DAY MONEY BACK GUARANTEE

  • MADE IN USA

  • GMP CERTIFIED

  • THIRD PARTY TESTED

  • ZERO FILLERS

  • 30 DAY MONEY BACK GUARANTEE

  • MADE IN USA

  • GMP CERTIFIED

  • THIRD PARTY TESTED

  • ZERO FILLERS

  • 30 DAY MONEY BACK GUARANTEE

Coffee's Real Secret

Boost NAD+ for Strength, Endurance, and Focus
1 3

Trigonelline

Backed by 2024 Nature Metabolism study
$52.90 $52.90

Trigonelline boosts NAD+ levels directly in muscle tissue—fueling ATP synthesis for peak cellular energy and healthy aging. By enhancing mitochondrial efficiency and red blood cell performance, it improves oxygen delivery to muscles, sustaining endurance, reducing fatigue, and powering strength for optimal performance.

Trigonelline enhances glucose uptake and insulin sensitivity to stabilize blood sugar, while supporting healthy fat metabolism and efficient glycogen storage—delivering sustained energy, improved endurance, and overall metabolic resilience.

Trigonelline boosts NAD+ to fuel neuronal energy and mitochondrial function, sharpening memory, focus, and learning. By enhancing neuroprotection, reducing neuroinflammation, and improving cerebral blood flow, it supports mental clarity, mood balance, and long-term brain health.

Customer Reviews

Based on 17 reviews
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E
Eugene
Very effective

Very effective, notice pretty rapidly, will be reordering.

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G
Gregory Deyermenjian
Trigonelline, up to now (just beginning)

I like all I have read and watched concerning Trigonelline, as well as all of its friendly and professional staff with whom I have dealt. I am at the beginning stages of using the product, and I have high expectations concerning its efficacy.

D
Dominic Vincent
Good coffee alternative

I love coffee but it doesn’t love me. These supplements provide me the boost I need without the downsides.

S
Stephen Andrade

Product definitely helps me focus

R
Rod Stair

Just received order yesterdayu

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NATURALLY FOUND IN COFFEE

Unlock Energy, endurance, and focus

Naturally found in coffee, Trigonelline is a potent NAD+ precursor that powers cellular energy, resilience, and performance. By elevating NAD+ directly in muscle and brain tissue, it fuels ATP synthesis for strength, endurance, and healthy aging.

Trigonelline enhances mitochondrial efficiency, oxygen delivery, and glucose metabolism—stabilizing blood sugar, optimizing fat utilization, and sustaining energy. It also sharpens memory, focus, and learning by supporting neuronal energy, neuroprotection, and cerebral blood flow.

Backed by emerging research and trusted by athletes and longevity enthusiasts, our 300mg Trigonelline capsules deliver clean, jitter-free performance and cognitive clarity.

Trigonelline Research

science-backed results

The lastest research behind trigonelline

Read more
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The Complete Benefits of Trigonelline: Cognitive Clarity, Strength, and Cellular Resilience

May 2025

Recent research reveals Trigonelline's role as a direct NAD⁺ precursor that supports everything from mental clarity to mitochondrial biogenesis, muscle strength to metabolic health. Unlike older precursors like NR or NMN, Trigonelline bypasses the liver, crosses the blood-brain barrier, and reaches muscle tissue directly.
Read More
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Trigonelline and the Brain: NAD+, Neuroprotection, and Cognitive Precision

May 2025

Trigonelline restores NAD⁺ directly in brain tissue. In the Nature Metabolism 2024 study, trigonelline was detected in cerebrospinal fluid, confirming central nervous system uptake - a level of access most NAD⁺ precursors never achieve. 
Read More
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Trigonelline for Peak Performance: The Molecule for Powering Strength, Endurance, and Recovery

April 2025

Recent Trigonelline research published on this naturally occurring alkaloid highlights its potential in enhancing muscle function and combating age-related decline.
Read More
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Trigonelline and Muscle Health: Insights from Nestlé's Research

February 2025

A 2024 study published in Nature Metabolism, conducted by researchers from EPFL in collaboration with the Nestlé Institute of Health Sciences identifies Trigonelline as a novel precursor to NAD+, a critical molecule for cellular energy production. 
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MORTALIS LABS TRIGONELLINE

Trigonelline Supplement FAQs

Trigonelline is a naturally occurring plant alkaloid best known for its role as an NAD+ precursor. Research shows it can increase NAD+ levels in muscle tissue, which supports energy, endurance, strength, and recovery. Mortalis Labs offers pure Trigonelline HCl (hydrochloride) which is the most stable and bioavailable form of Trigonelline available.

Trigonelline HCl: Highly stable and easily utilized by the body unlike other NAD+ cursors, and increases NAD+ most notably in muscle tissue.

NMN & NR: Raise systematic NAD+ levels and have poor bioavailability, meaning the body is not generally able to utilize the full serving that is consumed.

Raw NAD+: Not efficiently absorbed when taken orally, which is why people generally supplement with NAD+ precursors instead.

Mortalis Labs Trigonelline is the superior choice for athletic performance and recovery, with proven stability and bioavailability.

Many customers report increased muscle endurance, faster recovery after workouts, sharper cognitive function, and sustained daily energy. Results vary depending on diet, activity level, age, and whether Trigonelline is paired with other NAD+ precursors or other vitamins and supplements. We are not authorized to give medical advice nor make any health claims. The information on our website reflects the latest information based on scientific research and studies.

Each bottle contains 60 vegan capsules, with 300 mg of pure Trigonelline HCl per capsule and nothing else. We do not use any fillers or additives in our manufacturing process.

No. Our capsules contain only pure Trigonelline HCl. We do not add magnesium stearate, microcrystalline cellulose, or any other fillers or additives.

Yes. Every batch undergoes third-party lab testing to verify identity, purity, and potency. Our Trigonelline is manufactured in a cGMP-certified facility in the USA for safety and quality assurance.

Yes. Trigonelline can be safely paired with NMN and NR. NAD+ precursors have varying mechanisms of action (science-talk for saying that your body uses them differently and they affect different tissues). Combining multiple NAD+ precursors is generally regarded as an acceptable way to raise NAD+ levels in the body, noting that its possible for people to react differently or more favorably to certain NAD+ precursors.

Many prefer to take Trigonelline in the morning for steady energy throughout the day, and can be taken with or without food.